The Vehicle exploded near a bus station in al-Bab about 40km north-east of the city of Aleppo which wounded around 80 people.
Rescuers said that they were still searching for survivors amid the rubble of damaged buildings.
It is still unknownwho was behind the blast.
However, there have been a number of attacks in al-Bab since it was captured by rebels and Turkish troops from the Islamic State group in 2017.
Last November a car bombing had left 18 people dead and was blamed by Turkish authorities on the Syrian Kurdish People’s Protection Units (YPG) militia, which Ankara considers a terrorist organisation.
Two senior UN officials strongly condemned what they called the “horrific bombing” on Tuesday.
Imran Riza, humanitarian co-ordinator for Syria, and Kevin Kennedy, regional humanitarian co-ordinator for the Syria crisis, expressed their profound condolences to the families of the victims and urged all parties to the conflict in Syria to adhere to their obligations to ensure the safety of civilians.
